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2015
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1991-2000
1983-1990

    2015
  1. van Breemen RB. Development of safe and effective botanical dietary supplements. J Med Chem. 2015, Jul 21 Epub ahead of print.
  2. Parvinian A, Casadaban LC, Hauck ZZ, van Breemen RB, Gaba RC. Pharmacokinetic study of conventional sorafenib chemoembolization in a rabbit VX2 liver tumor model. Diagn Interv Radiol. 2015, 21:235-240. PMC4463267
  3. Huang K, Huang L, van Breemen RB. Detection of reactive metabolites using isotope-labeled glutathione trapping and simultaneous neutral loss and precursor ion scanning with ultra-high-pressure liquid chromatography triple quadrupole mass spectrometry. Anal Chem. 2015, 87:3646-3654. PMC4487545
  4. Cantuti-Castelvetri L, Maravilla E, Marshall M, Tamayo T, D'auria L, Monge J, Jeffries J, Sural-Fehr T, Lopez-Rosas A, Li G, Garcia K, van Breemen R, Vite C, Garcia J, Bongarzone ER. Mechanism of neuromuscular dysfunction in Krabbe disease. J Neurosci. 2015, 35:1606-1616. PMC4308604
  5. Pituch KC, Moyano AL, Lopez-Rosas A, Marottoli FM, Li G, Hu C, van Breemen RB, Månsson JE, Givogri MI. Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells. J Biol Chem. 2015, 290:7040-7053. PMC4358127
  6. 2014
  7. Simmler C, Jones T, Anderson JR, Nikoliċ DC, van Breemen RB, Soejarto DD, Chen S-N, Pauli GF. Species-specific standardization of licorice by metabolomic profiling of flavanones and chalcones. Phytochem Anal. 2014, 25:378-388. PMC4391967
  8. Yu LF, Brek Eaton J, Zhang HK, Sabath E, Hanania T, Li GN, van Breemen RB, Whiteaker P, Liu Q, Wu J, Chang YC, Lukas RJ, Brunner D, Kozikowski AP. The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile. Pharmacol Res Perspect. 2014, Apr;2(2):e00026. doi: 10.1002/prp2.26. PMC4184702
  9. Ramos Alvarenga RF, Friesen JB, Nikoliċ D, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S-N. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus). J Nat Prod. 2014, 77:2595-2604. PMC4280114
  10. Moyano AL, Li G, Lopez-Rosas A, Månsson JE, van Breemen RB, Givogri MI. Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry. Anal Biochem. 2014, 467:31-39.
  11. Simmler C, Nikoliċ D, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quemener C, Audo G, Pauli GF. Orthogonal analysis underscores the relevance of primary and secondary metabolites in licorice. J Nat Prod. 2014, 77:1806-1816. PMC4143180
  12. van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen S-N, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikoliċ D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Mol Nutr Food Res. 2014, 58:1962-1969. PMC4265473
  13. Yuan Y, Qiu X, Nikoliċ D, Chen S-N, Huang K, Li G, Pauli GF, van Breemen RB. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. Eur J Pharm Sci. 2014, 53:55-61. PMC3987852
  14. Newsome AG, Culver CA, van Breemen RB. Nature's palette: The search for natural blue colorants. J Agric Food Chem. 2014, 62:6498-6511.
  15. Garcia ME, Nicotra VE, Oberti JC, Rios-Luci C, Leon LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padron JM, Hueso-Falcon I, Estevez-Braun A. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives. Eur J Med Chem. 2014, 82:68-81.
  16. Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement. Biomed Chromatogr. 2014, 28:729-734. PMC4240625
  17. Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health, 2014 Apr 1, 13:25. PMC4066311
  18. Karalius VP, Harbison JE, Plange-Rhule J, van Breemen RB, Li G, Huang K, Durazo-Arvizu RA, Mora N, Dugas LR, Vail L, Tuchman NC, Forrester T, Luke A. Bisphenol A (BPA) found in humans and water in three geographic regions with distinctly different levels of economic development. Environ Health Insights. 2014, 8:1-3. PMC3891657
  19. Prins GS, Hu WY, Shi GB, Hu DP, Majumdar S, Li G, Huang K, Nelles JL, Ho SM, Walker CL, Kajdacsy-Balla A, van Breemen RB. Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Endocrinology. 2014, 155:805-817. PMC3929731
  20. Smith BR, Santos MB, Marshall MS, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, van Breemen R, Claycomb KI, Gallea JI, Celej MS, Crocker SJ, Givogri MI, Bongarzone ER. Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease. J Pathol. 2014, 232:509-521. PMC3977150
  21. Yoder M, Zhuge Y, Yuan Y, Holian O, Kuo S, van Breemen R, Thomas LL, Lum H. Bioactive lysophosphatidylcholine 16:0 and 18:0 are elevated in lungs of asthmatic subjects. Allergy Asthma Immunol Res. 2014, 6:61-65. PMC3881403
  22. Zhuge Y, Yuan Y, van Breemen R, Degrand M, Holian O, Yoder M, Lum H. Stimulated bronchial epithelial cells release bioactive lysophosphatidylcholine 16:0, 18:0, and 18:1. Allergy Asthma Immunol Res. 2014, 6:66-74. PMC3881404
  23. Van Loo-Bouwman CA, Naber TH, Minekus M, van Breemen RB, Hulshof PJ, Schaafsma G. Food matrix effects on bioaccessibility of β-carotene can be measured in an in vitro gastrointestinal model. J Agric Food Chem. 2014, 62:950-955. PMC3954432
  24. Nikoliċ D, Li J, van Breemen RB. Metabolism of Nω-methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes. Biomed Chromatogr. 2014 28:1647-1651. PMC4229456
  25. 2013
  26. Nikoliċ D, van Breemen RB. Analytical methods for quantitation of prenylated flavonoids from hops. Anal Chem. 2013, 9:71-85. PMC3783999
  27. Abdelkarim H, Brunsteiner M, Neelarapu R, Bai H, Madriaga A, van Breemen RB, Blond SY, Gaponenko V, Petukhov PA. Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution. ACS Chem Biol. 2013, 8:2538-2549.
  28. Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM. Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. Eur J Med Chem. 2013, 68:412-421.
  29. Eilati E, Hales K, Zhuge Y, Ansenberger Fricano K, Yu R, van Breemen RB, Hales DB. Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E(2) in laying hen ovaries. Prostaglandins Leukot Essent Fatty Acids. 2013, 89:179-187. PMC3811136
  30. Moyano AL, Pituch K, Li G, van Breemen R, Mansson JE, Givogri ML. Levels of plasma sulfatides C18:0 and C24:1 correlate with disease status in relapsing-remitting multiple sclerosis. J Neurochem. 2013, 127:600-604.
  31. Dong SH, Cai G, Napolitano JG, Nikoliċ D, Lankin DC, McAlpine JB, van Breemen RB, Soejarto DD, Pauli GF, Chen S-N. Lipidated steroid saponins from Dioscorea villosa (wild yam). Fitoterapia. 2013, 91:113-124. PMC3935402
  32. Mo S, Dong L, Hurst WJ, van Breemen RB. Quantitative analysis of phytosterols in edible oils using APCI liquid chromatography-tandem mass spectrometry. Lipids. 2013, 48:949-956. PMC4073239
  33. Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikoliċ D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS One. 2013 Jul 12;8(7):e67947. doi: 10.1371/journal.pone.0067947. Print 2013. PMC3709979
  34. van Breemen RB. Robert J. Cotter (1943-2012). J Am Soc Mass Spectrom. 2013, 24:655-656.
  35. Yu R, Zhao G, Christman JW, Xiao L, van Breemen RB. Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples. J AOAC Int. 2013, 96:67-76. PMC3723117
  36. Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikoliċ D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Mol Nutr Food Res. 2013, 57:1055-1066. PMC3864769
  37. Gaba RC, Yap FY, Martinez EM, Li Y, Guzman G, Parvinian A, van Breemen RB, Kumar N. Transarterial sorafenib chemoembolization: preliminary study of technical feasibility in a rabbit model. J Vasc Interv Radiol. 2013, 24:744-750. PMC3987856
  38. Qiu X, Yuan Y, Vaishnav A, Tessel MA, Nonn L, van Breemen RB. Effects of lycopene on protein expression in human primary prostatic epithelial cells. Cancer Prev Res (Phila). 2013, 6:419-27. PMC3644332 Featured in "Perspective" editorial in this issue by Sporn and Liby, p 384
  39. Jana A, Modi KK, Roy A, Anderson JA, van Breemen RB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. J Neuroimmune Pharmacol. 2013, 8:739-755. PMC3663914
  40. Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, Chen L, White JJ, van Breemen RB, Pezzuto JM, Cushman M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. J Med Chem. 2013, 56:2581-2605. PMC3623729
  41. Zhao G, Yu R, Deng J, Zhao Q, Li Y, Joo M, van Breemen RB, Christman JW, Xiao L. Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages. Mol Pharmacol. 2013, 83:167-178. PMC3533474
  42. Kabirov KK, Kapetanovic IM, Benbrook DM, Dinger N, Mankovskaya I, Zakharov A, Detrisac C, Pereira M, Martín-Jiménez T, Onua E, Banerjee A, van Breemen RB, Nikoliċ D, Chen L, Lyubimov AV. Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs. Drug Chem Toxicol. 2013, 36:284-295.
  43. Yuan Y, Yu LF, Qiu X, Kozikowski AP, van Breemen RB. Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective a4B2-nAChR partial agonist and promising antidepressant. J Chromatogr B Analyt Technol Biomed Life Sci. 2013, 912:38-42. PMC3538945
  44. 2012
  45. Yuan Y, Qiu X, Nikoliċ D, Dahl JH, van Breemen RB. Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum. J AOAC Int. 2012, 95:1744-1749. PMC3698037
  46. Dong SH, Nikoliċ D, Simmler C, Qiu F, van Breemen RB, Soejarto DD, Pauli GF, Chen SN. Diarylheptanoids from Dioscorea villosa (Wild Yam). J Nat Prod. 2012, 75:2168-77.
  47. Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons. J Med Chem. 2012, 55:10844-10862. PMC3542640
  48. Vaidya AS, Neelarapu R, Madriaga A, Bai H, Mendonca E, Abdelkarim H, van Breemen RB, Blond SY, Petukhov PA. Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorg Med Chem Lett. 2012, 22:6621-6627. PMC347134
  49. Vaidya AS, Karumudi B, Mendonca E, Madriaga A, Abdelkarim H, van Breemen RB, Petukhov PA. Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2. Bioorg Med Chem Lett. 2012, 22:5025-5030. PMC3401313
  50. Zhu H, Lopez-Rosas A, Qiu X, Van Breemen RB, Bongarzone ER. Detection of the neurotoxin psychosine in samples of peripheral blood: application in diagnostics and follow-up of Krabbe disease. Arch Pathol Lab Med. 2012, 136:709-710. PMC3664193
  51. Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. J Med Chem. 2012, 55:5965-81.
  52. Baumgarten S, Gaba RC, van Breemen RB. Confirmation of drug delivery after liver chemoembolization: direct tissue doxorubicin measurement by UHPLC-MS-MS. Biomed Chromatogr. 2012, 26:1529-33.
  53. Kondratyuk TP, Park EJ, Yu R, van Breemen RB, Asolkar RN, Murphy BT, Fenical W, Pezzuto JM. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs. 2012, 10:451-64. Free PMC Article
  54. van Breemen RB, Dong L, Pajkovic ND. Atmospheric pressure chemical ionization tandem mass spectrometry of carotenoids. Int J Mass Spectrom. 2012, 312:163-172. Free PMC Article
  55. Nikoliċ D, Gödecke T, Chen SN, White J, Lankin DC, Pauli GF, van Breemen RB. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia. 2012, 83:441-60. Free PMC Article
  56. Gaba RC, Baumgarten S, Omene BO, van Breemen RB, Garcia KD, Larson AC, Omary RA. Ethiodized oil uptake does not predict doxorubicin drug delivery after chemoembolization in VX2 liver tumors. J Vasc Interv Radiol. 2012, 23:265-73.
  57. Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1. Anal Biochem. 2012, 421:108-14. Free PMC Article
  58. Al-Alem U, Gann PH, Dahl J, van Breemen RB, Mistry V, Lam PM, Evans MD, Van Horn L, Wright ME. Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women. Genes Nutr. 2012, 7:191-5. Free PMC Article
  59. Gödecke T, Yao P, Napolitano JG, Nikoliċ D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF. Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 2012, 83:18-32. Free PMC Article
  60. 2011
  61. Gödecke T, Yao P, Napolitano JG, Nikolic D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF., Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 2011 Sep 1. [Epub ahead of print] Pubmed
  62. Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB., Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. J Pharmacol Exp Ther. 2011 Aug 24. [Epub ahead of print] Pubmed
  63. Li J, Gödecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikoliċ D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica. 2011 Aug 9. [Epub ahead of print] Pubmed
  64. Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM., Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res. 2011 Aug;55(8):1249-65. doi: 10.1002/mnfr.201100122. Epub 2011 Jun 29. Pubmed
  65. van Breemen RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE, Stacewicz-Sapuntzakis M., Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial. Cancer Prev Res (Phila). 2011 May;4(5):711-8. Epub 2011 Mar 23. Pubmed
  66. Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM., Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells. Cancer Prev Res (Phila). 2011 Apr;4(4):592-607.Pubmed
  67. Hu C, Eggler AL, Mesecar AD, van Breemen RB., Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol. 2011 Apr 18;24(4):515-21. Epub 2011 Mar 10. Pumed
  68. Castelvetri LC, Givogri MI, Zhu H, Smith B, Lopez-Rosas A, Qiu X, van Breemen RB, Bongarzone ER. Axonopathy is a compounding factor in the pathogenesis of Krabbe disease. Acta Neuropathol. 2011 Jul;122(1):35-48. Epub 2011 Mar 4. Pubmed
  69. 2010
  70. Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB., Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Analytical Chemistry. 2011 Feb 1;83(3):1048-52. Epub 2010 Dec 30. Pubmed
  71. Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ., Bioactive compounds from the fern Lepisorus contortus. J Nat Prod. 2011 Feb 25;74(2):129-36. Epub 2011 Jan 24. Pubmed
  72. Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, Fong HH, Farnsworth NR, Pauli GF., Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia. 2011 Jun;82(4):528-33. Epub 2010 Dec 13. Pubmed
  73. van Breemen RB, Tao Y, Li W., Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. Epub 2010 Sep 15.Pubmed
  74. Cao H, Yu R, Tao Y, Nikolic D, van Breemen RB., Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2011 Jan 5;54(1):230-5. Epub 2010 Aug 13.Pubmed
  75. Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, van Breemen R, Pezzuto JM., Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Res. 2010 Dec;30(12):4873-82. Pubmed
  76. Dong L, Shion H, Davis RG, Terry-Penak B, Castro-Perez J, van Breemen RB., Collision Cross-Section Determination and Tandem Mass Spectrometric Analysis of Isomeric Carotenoids Using Electrospray Ion Mobility Time-of-Flight Mass Spectrometry. Anal Chem. 2010 Oct 7. Pubmed
  77. Guo J, Peng D, Dai Q, Liao S, Wright BJ, van Breemen RB., Quantitative analysis of 3alpha,6alpha,24-trihydroxy-24,24-di(trifluoromethyl)-5beta-cholane, a potent synthetic steroidal liver X receptor agonist in plasma using liquid chromatography-tandem mass spectrometry. B, Analytical technologies in the biomedical and life sciences" J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1885-8. Pubmed
  78. Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M., Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. Pubmed
  79. Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL.Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chem Res Toxicol. 2010 Aug 16;23(8):1365-73. Pubmed
  80. Dahl JH, van Breemen RB., Rapid quantitative analysis of 8-iso-prostaglandin-F(2alpha) using liquid chromatography-tandem mass spectrometry and comparison with an enzyme immunoassay method. Anal Biochem. 2010 Sep 15;404(2):211-6. Epub 2010 May 25. Pubmed
  81. Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H., Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S284-94. Pubmed
  82. Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB., Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res. 2010 Jun;61(6):519-24. Epub 2010 Feb 24.Pubmed
  83. Van Loo-Bouwman CA, Naber TH, van Breemen RB, Zhu D, Dicke H, Siebelink E, Hulshof PJ, Russel FG, Schaafsma G, West CE., Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique. Br J Nutr. 2010 Jun;103(12):1836-43. Epub 2010 Feb 5. Pubmed
  84. Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 2010 Apr;71(5-6):641-7. Epub 2010 Jan 25. Pubmed
  85. Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM., Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila) . 2010 Feb;3(2):221-32. Epub 2010 Jan 12. Pubmed
  86. Nikoliċ D., A liquid chromatography-mass spectrometric assay for measuring activity of human 8-oxoguanine-DNA glycosylase. Anal Biochem. 2010 Jan 15;396(2):275-9. Epub 2009 Sep 24. Pubmed
  87. 2009
  88. He B, Velaparthi S, Pieffet G, Pennington C, Mahesh A, Holzle DL, Brunsteiner M, van Breemen R, Blond SY, Petukhov PA., Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors. J Med Chem. 2009 Nov 26;52(22):7003-7013. Pubmed
  89. Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, van Breemen RB, Kozikowski AP, Franzblau SG., From Serendipity to Rational Antituberculosis Drug Discovery of Mefloquine-Isoxazole Carboxylic Acid Esters., J Med Chem. 2009 Nov 26;52(22):6966-6978. Pubmed
  90. Tao Y, Li W, Liang W, Van Breemen RB., Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry., J Agric Food Chem. 2009 Nov 11;57(21):10014-21. Pubmed
  91. Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR., Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial., Menopause. 2009 Nov-Dec;16(6):1156-66. Pubmed
  92. Calderón AI, Wright BJ, Hurst WJ, van Breemen RB., Screening antioxidants using LC-MS: case study with cocoa., J Agric Food Chem. 2009 Jul 8;57(13):5693-9. Pubmed
  93. Gödecke T, Lankin DC, Nikolic D, Chen SN, van Breemen RB, Farnsworth NR, Pauli GF., Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa) (dagger)., J Nat Prod. 2009 Mar;72(3):433-7. Pubmed
  94. Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR., Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus., J Biol Chem. 2009 Mar 27;284(13):8633-42. Epub 2009 Jan 21. Pubmed
  95. Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF., Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts., Phytochem Anal. 2009 Mar;20(2):120-33. Pubmed
  96. 2008
  97. Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL., In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem. 2008 Dec 24;56(24):11718-26. Pubmed
  98. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR., Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metab Dispos. 2009 Jan;37(1):161-9. Epub 2008 Oct 20. Pubmed
  99. Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL., Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1., Chem Res Toxicol. 2008 Oct;21(10):1939-48. Epub 2008 Sep 23. Pubmed
  100. Ding S, Wang Y, Kolbanovskiy A, Durandin A, Bolton JL, van Breemen RB, Broyde S, Geacintov NE., Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry., Chem Res Toxicol. 2008 Sep;21(9):1739-48. Epub 2008 Aug 5. Pubmed
  101. Guo J, Liu A, Cao H, Luo Y, Pezzuto JM, van Breemen RB., Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases., Drug Metab Dispos. 2008 Oct;36(10):2104-12. Epub 2008 Jul 24. Pubmed
  102. Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL., In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin., Chem Biol Interact. 2008 Oct 22;176(1):30-9. Epub 2008 Jun 20. Pubmed
  103. van Breemen RB, Pajkovic N., Multitargeted therapy of cancer by lycopene., Cancer Lett. 2008 Oct 8;269(2):339-51. Epub 2008 Jun 27. Review. Pubmed
  104. van Breemen RB, Fong HH, Farnsworth NR., Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008 Feb;87(2):509S-13S. Pubmed
  105. Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG., The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. Am J Clin Nutr. 2008 Feb;87(2):504S-8S. Pubmed
  106. Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutr. 2008 Feb;87(2):476S-80S. PubMed
  107. Farnsworth NR, Krause EC, van Breemen RB, Graham JG. UIC / NIH Center for Botanical Dietary Supplements Research – translational research: from plant to clinical use. Am J Clin Nutr. 2008 Feb;87(2):504S-8S. PubMed
  108. van Breemen RB, Fong HHS, Farnsworth NR. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008Feb;87(2):509S-13S. PubMed
  109. Choi Y, van Breemen RB. Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. Comb Chem High Throughput Screen. 2008 Jan;11(1):1-6. PubMed
  110. 2007
  111. Cao H, Xiao L, Park G, Wang X, Azim AC, Christman JW, van Breemen RB. Abstract An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. Anal Biochem. 2008 Jan 1;372(1):41-51. Epub 2007 Sep 29. PubMed
  112. Galbiati F, Basso V, Cantuti L, Givogri MI, Lopez-Rosas A, Perez N, Vasu C, Cao H, van Breemen R, Mondino A, Bongarzone ER. Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease. J Neurosci. 2007 Dec 12;27(50):13730-8. PubMed
  113. Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. Screening for ligands of human retinoid X receptor-? using ultrafiltration mass spectrometry. Anal. Chem. 2007 Nov 13 eprint. PubMed
  114. Azim AC, Wang X, Park GY, Sadikot RT, Cao H, Mathew B, Atchison M, van Breemen RB, Joo M, Christman JW. NF-{kappa}B-Inducing Kinase Regulates Cyclooxygenase 2 Gene Expression in Macrophages by Phosphorylation of PU.1. J Immunol. 2007 Dec 1;179(11):7868-75. PubMed
  115. Guo J, Liu D, Nikolic D, Zhu D, Pezzuto JM, van Breemen RB. Free Full Text In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab Dispos. 2007 Nov 15; [Epub ahead of print] PubMed
  116. Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of Alkylation of Human Keap1 by Natural Chemoprevention Agents. J Am Soc Mass Spectrom. 2007 Oct 2; [Epub ahead of print] PubMed
  117. Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chem Res Toxicol. 2007 Oct 13; [Epub ahead of print]. PubMed
  118. Pang Y, Nikolic D, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Mol Nutr Food Res. 2007, 51, 872-879. PubMed
  119. Goo YA, Li Z, Pajkovic N, Shaffer S, Taylor G, Chen J, Campbell D, Arnstein L, Goodlett DR, van Breemen RB. Systematic investigation of lycopene effects in LNCaP cells by use of novel large-scale proteomic analysis software. Proteomics Clin. Appl. 2007 1, 513-523.
  120. Azim AC, Cao H, Gao X, Joo M, Malik AB, van Breemen RB, Sadikot RT, Park G, Christman JW. Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages. Am J Physiol Lung Cell Mol Physiol. 2007, 293, L668-673. PubMed
  121. Chen SN, Lankin DC, Nikolic D, Fabricant DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Chlorination diversifies Cimicifuga racemosa triterpene glycosides. J Nat Prod. 2007, 70, 1016-1023. PubMed
  122. van Breemen RB, Fong HH, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements. Chem Res Toxicol. 2007, 20, 577-582. Review. PubMed
  123. Li W, Xu X, Zhang H, Ma C, Fong H, van Breemen R, Fitzloff J. Secondary metabolites from Andrographis paniculata. Chem Pharm Bull (Tokyo). 2007, 55, 455-458. PubMed
  124. Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF. Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon). J Nat Prod. 2007, 70, 253-258. PubMed
  125. Mathew B, Park GY, Cao H, Azim AC, Wang X, van Breemen RB, Sadikot RT, Christman JW. Inhibitory Kappa B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages. Am. J. Respir. Cell Mol. Biol. 2007, 36, 562-572. PubMed
  126. 2006
  127. Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochem. Anal. 2006, 17, 398-405. PubMed
  128. Wang Z, Yuan H, Nikolic D, van Breemen RB, Silverman RB. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. Biochemistry 2006, 45, 14513-14522. PubMed
  129. Liu A, Pajkovic N, Pang Y, Zhu D, Calamini B, Mesecar A, van Breemen RB. Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol. Cancer Ther. 2006, 5, 2879-2885. PubMed
  130. Melse-Boonstra A, Verhoef P, West CE, van Rhijn JA, van Breemen RB, Lasaroms JJ, Garbis SD, Katan MB, Kok FJ. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am. J. Clin. Nutr. 2006, 84, 1128-1133. PubMed
  131. Kapetanovic IM, Krishnaraj R, Martin-Jimenez T, Yuan L, van Breemen RB, Lyubimov A. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics. Chem. Biol. Interact. 2006, 164, 68-75. PubMed
  132. Zhu D, Wang Y, Pang Y, Liu A, Guo J, Bouwman CA, West CE, van Breemen RB. Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies. Rapid Commun. Mass Spectrom. 2006, 20, 2427-2432. PubMed
  133. Nikolic D, Li Y, Chadwick LR, van Breemen RB. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm. Res. 2006, 23, 864-872. PubMed
  134. Mallavadhani UV, Narasimhan K, Sudhakar AV, Mahapatra A, Li W, van Breemen RB. Three new pentacyclic triterpenes and some flavonoids from the fruits of an Indian Ayurvedic plant Dendrophthoe falcata and their estrogen receptor binding activity. Chem. Pharm. Bull (Tokyo) 2006, 54, 740-744. PubMed
  135. Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J. Nat. Prod. 2006, 69, 536-541. PubMed
  136. Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug Metab. Dispos. 2006, 34, 1152-1159. PubMed
  137. Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. The chemical and biologic profile of a red clover ( Trifolium pratense L.) phase II clinical extract. J. Altern. Complement Med. 2006, 12, 133-139. PubMed
  138. 2005
  139. van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol. 2005, 1:175-185. PubMed
  140. van Breemen RB. How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia? J Nutr. 2005, 135:2062S-4S. PubMed
  141. Cheng X, van Breemen RB. Mass spectrometry-based screening for inhibitors of β-amyloid protein aggregation. Anal Chem. 2005, 77:7012-7015. PMC1780175 PubMed
  142. Li Y, Yang X, Chang M, Yager JD, van Breemen RB, Bolton JL. Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase. Chem Biol Interact. 2005, 152:151-163 (2005). Pubmed
  143. Chow AW, Murillo G, Yu C, van Breemen RB, Boddie AW, Pezzuto JM, Das Gupta TK, Mehta RG. Resveratrol inhibits rhabdomyosarcoma cell proliferation. Eur J Cancer Prev. 2005, 14:351-356. PubMed
  144. Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase. Chem Res Toxicol. 2005, 18:1296-1305. PubMed
  145. Eggler AL, Liu G, Pezzuto JM, van Breemen RB and Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci USA. 2005, 102:10070-10075. PMC1177374 PubMed
  146. Fabricant DS, Nikoliċ D, Lankin DC, Chen SN, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR and Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa. J Nat Prod. 2005, 68:1266-1270. PubMed
  147. Li Y, Yang X, van Breemen RB, Bolton JL. Characterization of two new variants of human catechol O-methyltransferase in vitro. Cancer Lett. 2005, 230:81-89. PubMed
  148. Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal Chem. 2005, 77:6407-6414. PubMed
  149. Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chem Res Toxicol. 2005, 18:162-173. PubMed
  150. Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chem Res Toxicol. 2005, 18:1485-1496. PMC2517578 PubMed
  151. Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chem Res Toxicol. 2005, 18:174-182. PubMed
  152. Overk CR, Yao P, Chadwick LR, Nikoliċ D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005, 53:6246-6253. PMC1815392 PubMed. *This paper was cited by the NIH in the Annual Bibliography of Significant Advances in Dietary Supplement Research, 2005. Ed. by Costello RB, Saldanha LG. NIH Publication No. 06-6060, September 2006.
  153. Sun Y, Li W, Fitzloff JF, van Breemen RB. Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba. J Mass Specrom. 2005, 40:373-379. PMC1852454 PubMed
  154. Constantinou AI, White BEP, Tonetti D, Yang Y, Liang W, Li W, van Breemen RB. The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur J Cancer. 2005, 41:647-654. PubMed
  155. Kobayashi T, Yang X, Walker LA, van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: Identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol. 2005, 38:213-218. PubMed
  156. Zhu Y, Nikoliċ D, van Breemen, RB, Silverman RB. Mechanism of inactivation of inducible nitric oxide synthase by amidines irreversible enzyme inactivation without inactivator modification. J Am Chem Soc. 2005, 127:858-868. PubMed
  157. Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. J Am Soc Mass Spectrom. 2005, 16:271-279. PMC1780173 PubMed
  158. Nikolic D, Li Y, Chadwick LR, Pauli GF, van Breemen RB. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J Mass Spectrom. 2005, 40:289-299. PubMed
  159. 2004
  160. Singletary KW, Barnes SL, van Breemen RB. Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells. Cancer Lett. 2004, 203:139-144. PubMed
  161. Nikoliċ D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab Dispos. 2004, 32:272-279. PubMed.
  162. Yang X, Wu H, Kobayashi T, Solaro RJ, van Breemen RB. Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry. Anal Chem. 2004, 76:1532-6. PubMed
  163. Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikoliċ D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004, 11:18-23. PubMed
  164. Nikoliċ D, van Breemen RB. New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab Dispos. 2004, 32:387-397. PubMed
  165. Li Y, Yao J, Chang M, Nikoliċ D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chem Res Toxicol. 2004, 17:512-520. PubMed
  166. Piersen CE, Booth NL, Sun Y, Liang W, Burdette JE, van Breemen RB, Geller SE, Gu C, Banuvar S, Shulman LP, Bolton JL, Farnsworth NR. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. Cur Med Chem. 2004, 11:1361-1374. PubMed
  167. Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher RJ, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chem Res Toxicol. 2004, 17:879-888. PubMed
  168. Li Y, Grubjesic S, Nikolic D, Zhu D, Kosmeder J, Moriarty RM, Pezzuto JM, van Breemen RB. In vitro assessment of intestinal permeability and hepatic metabolism of 4’-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica, 2004, 34:535-547. PubMed
  169. Li W, Sun Y, van Breemen RB, Fitzloff JF. Evaluation of major caffeic acid derivatives in Echinacea purpurea dietary supplements by HPLC with photodiode array detection and electrospray mass spectrometry. J. Liq Chromatogr Rel Technol. 2004, 27:2507-2529.
  170. Booth NL, Nikolic D, van Breemen RB, Geller SE, Banuvar S, Shulman LP, Farnsworth NR. Confusion regarding anticoagulant coumarins in dietary supplements. Clin Pharmacol Therapeut. 2004, 76:511-516. PubMed
  171. Mariappan SV, Cheng X, van Breemen RB, Silks LA, Gupta G. Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry. Anal Biochem. 2004, 334:216-226. PubMed
  172. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Frohlich R, Fong HHS, Farnsworth NR, Pauli GF. Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod. 2004, 67:2024-2032. PubMed
  173. 2003
  174. van Lieshout M, West CE, van Breemen RB. Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly β-carotene, in humans: a review. Am J Clin Nutr. 2003, 77:12-28. PubMed
  175. Su B-N, Cuendet M, Nikoliċ D, Kristinsson H, Ingolfsdottir K, van Breemen RB, Fong HHS, Pezzuto JM, Kinghorn AD. NMR study of fumarprotocetraric acid, a complex lichen depsidone derivative from Cladonia furcata. Magn Reson Chem, 2003, 41:391-394. PubMed
  176. Gu J-Q, Li W, Kang Y-H, Su B-N, Fong HHS, van Breemen RB, Pezzuto JM, Kinghorn AD. Minor withanolides from Physalis philadelphica: Structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation of artifacts. Chem Pharm Bull (Tokyo), 2003, 51:530-539. PubMed
  177. Li W, Sun Y, Liang W, Fitzloff JF, van Breemen RB. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003, 17:978-982. PubMed
  178. Johnson BM, Qiu S-X, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB. Identification of novel electrophilic mammalian metabolites of Piper methysticum Forst. (Kava). Chem Res Toxicol. 2003, 16:733-740. PubMed
  179. Liu X, Zhang F, Liu H, Burdett JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem Res Toxicol. 2003, 16:741-749. PubMed
  180. Kouloumbos VN, Tsipi DF, Hiskia AE, Nikoliċ D, van Breemen RB. Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry. J Am Soc Mass Spectrom. 2003, 14:803-817. PubMed
  181. Su B-N, Park EJ, Nikoliċ D, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HHS, Farnsworth NR, Pezzuto JP, Kinghorn AD. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J Nat Prod. 2003, 66:1089-1093. PubMed
  182. Cheng X, Shin YG, Levine BS, Smith AC, Tomaszewski JE, van Breemen RB. Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray LC-MS. Rap Commun Mass Spectrom, 2003, 17:2089-2092. PubMed
  183. Johnson BM, van Breemen RB. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh). Chem Res Toxicol. 2003, 16:838-846. PubMed
  184. van Lieshout M, West CE, van de Bovenkamp P, Wang Y, Sun Y, van Breemen RB, Muhilal DP, Verhoeven MA, Creemers AFL, Lugtenburg J. Extraction of carotenoids from feces, enabling the bioavailability of β-carotene to be studied in Indonesian children. J Agric Food Chem. 2003, 51:5123-5130. PubMed
  185. Burdette JE, Liu J, Chen S-N, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.J Agric Food Chem. 2003, 51:5661-5670. PubMed
  186. Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB. Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem. 2003, 51:5867-5870. PubMed
  187. Lu X, Nikoliċ D, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. A mechanism for substrate-induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorg Med Chem Lett. 2003, 13:4129-4132. PubMed
  188. Singletary KW, Stansbury MJ, Giusti M, van Breemen RB, Wallig M, Rimando A. Inhibition of rat mammary tumorigenesis by concord grape juice constituents. J Agric Food Chem. 2003, 51:7280-7286. PubMed
  189. Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: Application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen. 2003, 6:757-767. PubMed
  190. Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chem Res Toxicol. 2003, 16:668-675. PubMed
  191. Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun Mass Spectrom. 2003, 17:307-313. PubMed
  192. Su B-N, Park EJ, Nikoliċ D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HSS, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity. J Org Chem. 2003, 68:2350-2361 PubMed
  193. Fang L, Pajkoviċ N, Wang Y, Gu C, van Breemen RB. Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem. 2003, 75:812-817. PubMed
  194. 2002
  195. Li W, Sun Y, Joseph J, Fitzloff JF, Fong HHS, van Breemen RB. p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products. J Agric Food Chem. 2002, 51:524-529. PubMed
  196. Yu C, Shin YG, Chow A, Li Y, Kosmeder JW, Lee YS, Hirschelman WH, Pezzuto JM, Mehta RG, van Breemen RB. Human, rat, and mouse metabolism of resveratrol. Pharmaceut Res. 2002, 19:1907-1914. PubMed
  197. Johnson BM, Nikoliċ D, van Breemen RB. Application of pulsed ultrafiltration-mass spectrometry. Mass Spectrom Rev. 2002, 21:76-86. PubMed
  198. Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, Kim HS, Christov-Tzelkov K, van Breemen R. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med. (Maywood, NJ, United States) 2002, 227:886-893. PubMed
  199. Burdette JE, Chen S-N, Lu ZZ, Xu H, White BEP, Fabricant DS, Liu J, Fong HHS, Farnsworth NR, Constantinou AI, van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles. J Agric Food Chem. 2002, 50:7022-7028. PubMed
  200. van Breemen, RB, Bolton JL, Johnson BM. Rapid in vitro screening of botanical dietary supplements and pharmaceuticals for metabolic activation to electrophilic metabolites: Validation by detection of corresponding mercapturates in urine. Drug Metab Rev. 2002, 34:394 Suppl. 1.
  201. Yang Y, Nikoliċ D, Swanson SM, van Breemen RB. Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS. Anal Chem. 2002, 74:5376-5382. PubMed
  202. Li W, Sun Y, Fitzloff JF, van Breemen RB. Evaluation of commercial ginkgo and Echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry. Chem Res Toxicol. 2002, 15:1174-1178. PubMed
  203. Prins GS, Chang WY, Wang Y, van Breemen RB. Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure. Endocrinology, 2002, 143:3628-3640. PubMed
  204. Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB. An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem. 2002, 50:431-435. Pubmed
  205. Papadantonakis GA, Tranter R, Brezinsky K, Yang Y, van Breemen RB, LeBreton PR. Low-energy, low-yield photoionization, and production of 8-oxo-2'-deoxyguanosine and guanine from 2'-deoxyguanosine. J Phys Chem B. 2002, 106:7704-7712. Abstract
  206. Constantinou AI, Lucas LM, Lantvit D, Hawthorne M, Xu X, Nho CW, Jeffery EH, Christov K, van Breemen RB, Pezzuto JM. Soy protein isolate prevents chemically-induced rat mammary tumors. Pharmaceut Biol. (Lisse, Netherlands) 2002, 40:24-34.
  207. Liu X, Yao J, Pisha E, Yang Y, Hua Y, van Breemen RB, Bolton JL. Oxidative DNA damage induced by equine estrogen metabolites: Role of estrogen receptor-α. Chem Res Toxicol. 2002, 15:512-519. PubMed
  208. Shin YG, Bolton JL, van Breemen RB. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Comb Chem High Throughput Screen. 2002, 5:59-64. PubMed
  209. Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KPL, Hedayat S, van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr 2002, 132:27-30. PubMed
  210. van Breemen RB, Xu X, Viana MA, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Bowen PE, Sharifi R. Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce. J Agric Food Chem. 2002, 50:2214-2219. PubMed
  211. 2001
  212. Shin YG, van Breemen RB. Analysis and screening of combinatorial libraries using mass spectrometry. Biopharmaceutics Drug Dispos. 2001, 22:353-372. PubMed
  213. Constantinou AI, Lantvit D, Hawthorne M, Xu X, van Breemen RB, Pezzuto JM. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr Cancer 2001, 41:75-81. PubMed
  214. Zhang F, Swanson SM, van Breemen RB, Liu X, Yang Y, Gu C, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: Formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chem Res Toxicol. 2001, 14:1654-1659. PubMed
  215. Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL. Synthesis and reactivity of potential toxic metabolites of Tamoxifen analogues: Droloxifene and toremifene o-quinones. Chem Res Toxicol. 2001, 14:1643-1653. PubMed
  216. Mitchell DJ, Nikoliċ D, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct. Bioorg Med Chem Lett. 2001, 11:1757-1760.
  217. Mitchell DJ, Nikoliċ D, Jang MH, van Breemen RB, Hille R, Silverman RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-α-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry, 2001, 40:8523-8530.
  218. van Lieshout M, West CE, Muhilal, Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AF, Verhoeven MA, Lugtenburg J. Bioefficacy of β-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr. 2001, 73:949-958.
  219. Mitchell DJ, Nikoliċ D, Rivera E, Sablin SO, Choi S, van Breemen RB, Singer TP, Silverman, RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry, 2001, 40:5447-5456.
  220. Garbis SD, Melse-Boonstra A, West CE, van Breemen RB. Determination of folates in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry. Anal Chem. 2001, 73:5358-5364. PubMed
  221. Johnson BM, Bolton JL, van Breemen RB. Screening botanical extracts for quinoid metabolites. Chem Res Toxicol. 2001, 14:1546-1551. PubMed
  222. Wang Y, Chang WY, Prins GS, van Breemen RB. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry. J Mass Spectrom. 2001, 36:882-888. PubMed
  223. Zhang F, Yao D, Hua Y, van Breemen RB, Bolton JL. Synthesis and reactivity of catechol metabolites from equine estrogen 8,9-dehydroestrone. Chem Res Toxicol. 2001, 14:754-763. PubMed
  224. Park EJ, Lee D, Shin YG, Lantvit DD, van Breemen RB, Kinghorn AD, Pezzuto JM. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001, 754:327-332. PubMed
  225. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KPL, Booth N, Constantinou AI, Pezzuto JM, Fong HHS, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001, 49:2472-2479.
  226. Chang M, Shin Y-G, van Breemen RB, Blond SY, Bolton JL. Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. Biochemistry, 2001, 40:4811-4820.
  227. Wang Y, Chang WY, Prins GS, van Breemen RB. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry. J Mass Spectrom. 2001, 36:882-888.
  228. Nikoliċ D, van Breemen RB. DNA Oxidation induced by cyclooxygenase-2. Chem Res Toxicol. 2001, 14:351-354.
  229. Nikoliċ D, van Breemen RB. DNA oxidation induced by cyclooxygenase-2. Chem Res Toxicol. 2001, 14:351-354.
  230. Hua Y, Wainhaus SB, Yang Y, Shen L, Xiong Y, Xu X, Zhang F, Bolton JL, van Breemen RB. Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides. J Am Soc Mass Spectrom. 2001, 12:80-87.
  231. 1991-2000
  232. Hamm ML, Nikoliċ D, van Breemen RB, Piccirilli JA. Unconventional origin of metal ion rescue in the hammerhead ribozyme reaction: Mn2+-assisted redox conversion of 2’-mercaptocytidine to cytidine. J Am Chem Soc. 2000, 122:12069-12078.
  233. Li W, Gu C, Zhang H, Awang DVC, Fitzloff JF, Fong HHS, van Breemen RB. Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal Chem. 2000, 72:5417-5422.
  234. Nikoliċ D, Habibi-Goudarzi S, Corley DG, Gafner S, Pezzuto JM, van Breemen RB. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry. Anal Chem. 2000, 72:3853-3859.
  235. Wang Y, Xu X, van Lieshout M, West CE, Lugtenburg J, Verhoeven MA, Creemers AFL, Muhilal, van Breemen RB. A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of β-carotene to retinol in humans. Anal Chem. 2000, 72:4999-5003.
  236. Henry LK, Puspitasari-Nienaber NL, Jaren-Galan, M, van Breemen RB, Catignani G, Schwartz SJ. Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system. J Agric Food Chem. 2000, 48:5008-5013.
  237. Westenburg HE, Lee K-J, Lee SK, Fong HH, van Breemen RB, Pezzuto JM, Kinghorn AD. Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J Nat Prod. 2000 63:1696-1698.
  238. Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem Res Toxicol. 2000, 13:342-350.
  239. Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of Tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Chem Res Toxicol. 2000, 13:53-62.
  240. Gu C, Nikoliċ D, Lai J, Xu X, van Breemen RB. Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry. Comb Chem High Throughput Screen. 1999, 2:353-359.
  241. Fu M, Nikoliċ D, van Breemen RB, Silverman RB. Mechanism of inactivation of g-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid. J Am Chem Soc. 1999 121:7751-7759.
  242. Xu X, Wang Y, Constantinou AI, Stacewicz-Sapuntzakis M, Bowen PE, van Breemen RB. Solubilization and stabilization of carotenoidcs using micelles: delivery of lycopene to cells in culture. Lipids 1999, 34:1031-1036.
  243. Korecka M, Nikoliċ D, van Breemen RB, Shaw LM. The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid. Clin Chem. 1999, 45:1047-1059.
  244. Hadden WL, Watkins RH, Levy LW, Regalado E, Rivadeneira DM, van Breemen RB, Schwartz SJ. Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement. J Agric Food Chem. 1999, 47:4189-4194.
  245. Fast W, Nikoliċ D, van Breemen R, Marletta MA, Silverman RB. Mechanistic studies of the inactivation of inducible nitric oxide synthase by N5-(1-iminoethyl)-L-ornithine (L-NIO). J Am Chem Soc. 1999, 121:903-916.
  246. Nikoliċ D, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Comb Chem High Throughput Screen. 1999, 2:165-176.
  247. Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chem Res Toxicol. 1999, 12:204-213.
  248. Chung HS, Chang LC, Lee SK, Shamon LA, van Breemen RB, Mehta RG, Farnsworth NR, Pezzuto JM, Kinghorn AD. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity. J Agric Food Chem. 1999, 47:36-41.
  249. Shaw LM, Korecka M, van Breemen R, Nowak I, Brayman KL. Analysis, pharmacokinetics and therapeutic drug monitoring of mycophenolic acid. Clin Biochem. 1998 31:323-328.
  250. Ito A, Shamon LA, Yu B, Mata-Greenwood E, Lee SK, van Breemen RB, Mehta RG, Farnsworth NR, Fong HHS, Pezzuto JM, Kinghorn AD. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity. J Agric Food Chem. 1998, 46:3509-3516.
  251. Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikoliċ D, Bolton JL. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chem Res Toxicol. 1998, 11:1105-1111.
  252. Chang M, Zhang F, Shen L, Pauss N, Alam I, van Breemen RB, Blond SY, Bolton JL. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens. Chem Res Toxicol. 1998, 11:758-765.
  253. van Breemen RB, Tan Y, Lai J, Huang C-R, Zhao X. Immobilized thymine chromatography-mass spectrometry of oligonucleotides. J Chromatogr A. 1998, 806:67-76.
  254. Nikoliċ D, van Breemen RB. Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. Comb Chem High Throughput Screen. 1998, 1:47-55.
  255. Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikoliċ D, Bolton JL. Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chem Res Toxicol. 1998, 11:94-101.
  256. van Breemen RB, Nikoliċ D, Bolton JL. Metabolic screening using online ultrafiltration mass spectrometry. Drug Metab Dispos. 1998, 26:85-90.
  257. van Breemen RB, Nikoliċ D, Xu X, Xiong Y, van Lieshout M, West CE, Schilling AB. Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. J Chromatogr A. 1998, 794:245-251.
  258. Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, van Breemen RB, Pezzuto JM. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells. Chem-Biol Interact. 1997, 106:133-148.
  259. Zhang HQ, Dixon RP, Marletta MA, Nikoliċ D, van Breemen R, Silverman RB. Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine. J Am Chem Soc. 1997, 119:10888-10902.
  260. Zhao YZ, van Breemen RB, Nikoliċ D, Huang C-R, Woodbury CP, Schilling A, Venton DL. Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J Med Chem 1997, 40:4006-4012.
  261. Shen L, Qiu S, van Breemen RB, Zhang F, Chen Y, Bolton JL. Reaction of the Premarin metabolite 4-hydroxyequilenin semiquinone radical with 2'-deoxyguanosine: formation of unusual cyclic adducts. J Am Chem Soc. 1997, 119:11126-11127.
  262. van Breemen RB. Liquid chromatography/mass spectrometry of carotenoids. Pure Applied Chem. 1997, 69:2061-2066.
  263. Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL. Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis 1997, 18:1093-1101.
  264. van Breemen RB, Huang CR, Nikoliċ D, Woodbury CP, Zhao YZ, Venton DL. Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal Chem. 1997, 69:2159-2164.
  265. van Breemen RB, Huang CR, Tan Y, Sander LC, Schilling AB. Liquid chromatography/mass spectrometry of carotenoids using atmospheric pressure chemical ionization. J Mass Spectrom. 1996, 31:975-981.
  266. van Breemen RB, Huang C-R. High-performance liquid chromatography-electrospray mass spectrometry of retinoids. FASEB J. 1996, 10:1098-1101.
  267. van Breemen RB. Innovations in carotenoid analysis using LC/MS. Anal Chem. 1996, 68:299A-304A. *This paper was featured on the cover page of this issue of Analytical Chemistry.
  268. van Breemen RB, Huang CR, Lu ZZ, Rimando A, Fong HHS, Fitzloff JF. Electrospray liquid chromatography/mass spectrometry of ginsenosides. Anal Chem. 1995, 67, 3985-3989.
  269. van Breemen RB. Electrospray liquid chromatography-mass spectrometry of carotenoids. Anal Chem. 1995, 67:2004-2009.
  270. Thomas VR, Schreiner AF, van Breemen R, Xie T-Y, Chen C-L, Gratzl JS, Photolytic dechlorination of 4-chlorophenol using an ArF* excimer laser. Holzforschung, 1995, 49:139-145.
  271. van Breemen RB. Advances in carotenoid analysis: Electrospray liquid chromatography-mass spectrometry using C30 reversed phase HPLC. Carotenoid News, 1995, 5:8-9.
  272. van Breemen RB, Jian O, Tidwell RR, Hall JE, Brewer TG. Fast atom bombardment tandem mass spectrometry of the anti-parasitic agent pentamidine and its oxygenated metabolites. J Mass Spectrom. 1995, 30:549-556.
  273. van Breemen RB, Schmitz HH, Schwartz SJ. Fast atom bombardment tandem mass spectrometry of carotenoids. J Agric Food Chem. 1995, 43:384-389.
  274. Spanos GA, Schwartz SJ, van Breemen RB, Huang C-H. High-performance liquid chromatography with light-scattering detection and desorption chemical-ionization tandem mass spectrometry of milk fat triacylglycerols. Lipids, 1995, 30:85-90.
  275. van Breemen RB, Tsou Y, Connolly G. Oxidation of dicyclopentadiene in surface water. Biol Mass Spectrom. 1993, 22:579-584.
  276. Blackburn RK, van Breemen RB. Degradation of the cyclic peptide antibiotic lysobactin by immobilized digestive proteases. Drug Metab Dispos. 1993, 21:573-579.
  277. Oommen TV, Petrie EM, van Breemen RB, Haney CA. Analysis of furanic compounds from cellulose aging by GC-MS, and attempts to correlate with degree of polymerization. CIGRE Paper 110-02, CIGRE Symposium on Diagnostic and Maintenance Techniques. Berlin, Germany, April 19-21. 1993.
  278. Saljoughian M, Williams PG, Morimoto H, Goodlett DR, van Breemen RB. Tritiated diimide: A regio- and stereo-selective tritium labeling reagent. J Chem Soc, Chem Commun. 1993, 414-416.
  279. van Breemen RB, Schmitz HH, Schwartz SJ. Continuous-flow fast atom bombardment liquid chromatography/mass spectrometry of carotenoids. Anal Chem. 1993, 65:965-969.
  280. van Breemen RB, Davis RG. Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectrometry. Anal Chem. 1992, 64:2233-2237.
  281. Schmitz HH, van Breemen RB, Schwartz SJ. Applications of fast atom bombardment mass spectrometry (FAB-MS) and continuous-flow FAB-MS to carotenoid analysis. Methods Enzymol. 1992, 213:322-336.
  282. Bumgardner CL, Huang C-H, van Breemen RB. Characterization of oligomers of 3,3,3-trifluoro-1-phenylpropyne and 1-phenylpropyne by mass spectrometry. J Fluor Chem. 1992, 56:175-187.
  283. van Breemen RB, Huang C-H, Bumgardner CL. Continuous-flow fast atom bombardment and field desorption mass spectrometry of oligomers of 3,3,3-trifluorophenylpropyne. Anal Chem. 1991, 63:2577-2580.
  284. Freeman HS, Hao Z, Sokolowska-Gajda J, van Breemen RB. Matrix selection in the FAB mass spectrometric analysis of synthetic dyes. Dyes Pigments, 1991, 16:317-327.
  285. van Breemen RB, Canjura FL, Schwartz SJ. Identification of chlorophyll derivatives by mass spectrometry. J Agric Food Chem. 1991, 39:1452-1456.
  286. van Breemen RB, Bartlett MG, Tsou Y, Culver C, Swaisgood H, Unger SE. Degradation of peptide drugs by immobilized digestive proteases. Drug Metab Dispos. 1991, 19:683-690.
  287. van Breemen RB, Canjura FL, Schwartz SJ. High-performance liquid chromatography-continuous-flow mass spectrometry of chlorophyll derivatives. J Chromatogr. 1991, 542:373-383.
  288. van Breemen RB, Martin LB, Le JC. Continuous-flow fast atom bombardment mass spectrometry of oligonucleotides. J Am Soc Mass Spectrom. 1991, 2:157-163.
  289. Martin LB, Schreiner AF, van Breemen RB. Characterization of cisplatin adducts of oligonucleotides by fast atom bombardment mass spectrometry. Anal Biochem. 1991 193:6-15.
  290. 1983-1990
  291. Freeman HS, van Breemen RB, Esancy JF, Hao Z, Ukponmwan DO, Hsu W-N. Fast atom bombardment and desorption chemical ionization mass spectrometry in the analysis of involatile textile dyes. Textile Chemist Colorist, 1990, 22:23-28.
  292. van Breemen RB, Wheeler JJ, Boss WF. Identification of carrot inositol phospholipids by fast atom bombardment mass spectrometry. Lipids, 1990, 25:328-334.
  293. Goodlett DR, Armstrong FB, Creech RJ, van Breemen RB. Formylated peptides from cyanogen bromide digests identified by fast atom bombardment mass spectrometry. Anal Biochem. 1990, 186:116-120.
  294. van Breemen RB, Martin LB, Schreiner AF. Formation of Negative ions of monosubstituted Group VIB pentacarbonyls during fast atom bombardment mass spectrometry. Org Mass Spectrom. 1990, 25:3-8.
  295. van Breemen RB, Le JC. Enhanced sensitivity of peptide analysis by fast atom bombardment mass spectrometry using nitrocellulose as a substrate. Rapid Commun Mass Spectrom. 1989, 3:20-24.
  296. van Breemen RB. Fast atom bombardment mass spectrometry with B/E linked scanning of ether- and thiophenol-linked glucuronides. In Cellular and Molecular Aspects of Glucuronidation, ed. by G. Siest, J. Magdalou, B. Burchell, vol. 173, pp. 211-9, Colloque INSERM/John Libbey Eurotext Ltd., 1988.
  297. van Breemen RB, Stogniew M, Fenselau C. Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry. Biomed Environ Mass Spectrom. 1988, 17:97-103.
  298. van Breemen RB, Martin LB, Schreiner AF. Comparison of electron impact, desorption chemical ionization, field desorption, and fast atom bombardment mass spectra of nine monosubstituted Group VI metal carbonyls. Anal Chem. 1988, 60:1314-1318.
  299. Fenselau C, van Breemen R, Bradow G, Stogniew M. Acyl-linked glucuronides as reactive metabolites. Fed Proc. 1987, 46:2436-2439.
  300. van Breemen RB, Fenselau C, Cotter RJ, Curtis AJ, Connolly G. Derivatives of dicyclopentadiene in ground water. Biomed Environ Mass Spectrom. 1987, 14:97-102.
  301. van Breemen RB, Fenselau C, Mogilevsky W, Odell GB. Reaction of bilirubin glucuronides with serum albumin. J Chromatogr. 1986, 383:387-392.
  302. van Breemen RB, Fenselau C. Reaction of 1-O-acyl glucuronides with 4-p-(nitrobenzyl)pyridine. Drug Metab Dispos. 1986, 14:197-201.
  303. van Breemen RB, Fenselau C. Acylation of albumin by 1-O-acyl glucuronides. Drug Metab Dispos. 1985, 13:318-20.
  304. van Breemen RB, Tabet J-C, Cotter RJ. Characterization of oxygen-linked glucuronides by laser desorption mass spectrometry. Biomed Mass Spectrom. 1984, 11:278-83.
  305. Gibson W, van Breemen R, Fields A, LaFemina R, Irmiere A. D,L-α-Difluoromethylorinithine inhibits human cytomegalovirus replication. J Virology. 1984, 50:145-154.
  306. van Breemen RB, Snow M, Cotter RJ. Time resolved laser desorption mass spectrometry, I. Desorption of preformed ions. Int J Mass Spectrom Ion Phys. 1983, 49:35-50.
  307. Cotter RJ, van Breemen R, Yergey J, Heller D. Thermal, laser, and fast atom desorption. Int J Mass Spectrom Ion Proc. 1983, 46:395-398.
Chapters in Books
  1. Newsome AG, Murphy BT, van Breemen RB. Isolation and characterization of natural blue pigments from underexplored sources. In Physical Methods in Food Analysis. Ed. by Tunick MH, Onwulate CI. American Chemical Society Books, Volume 1138, pp 105-125, 2013
  2. van Breemen RB, Martinez E. Best practices in mass spectrometry for LC-MS. In Handbook of LC-MS Bioanalysis. Ed. by Li W, Zhang J, Tse FLS. John Wiley & Sons, Hoboken, NJ, pp 205-216, 2013
  3. van Breemen RB. Chapter 5: Pharmaceutical Applications: On-line ultrafiltration mass spectrometry, principles and applications. In Encyclopedia of Mass Spectrometry Volume 8: Hyphenated Methods. Ed. by Niessen WM. Elsevier Science, Oxford, UK, pp 515-522, 2006
  4. Fong HHS, Pauli GF, Bolton JL, van Breemen RB, Banuvar S, Shulman L, Geller SE, Farnsworth NR. Chapter 2: Evidence-based herbal medicine: Challenges in efficacy and safety assessments. In Annals of Traditional Chinese Medicine – Vol. 2. Current Review of Chinese Medicine: Quality Control of Herbs and Herbal Medicine. Ed. by Leung PC, Fong H, Xue CC. World Scientific, New Jersey, pp 11-26, 2006
  5. van Breemen RB. Chapter 4: Natural products from plants. In The Encyclopedia of Mass Spectrometry, Volume 3: Biological Applications, Part B: Carbohydrates, Nucleic Acids and other Biological Compounds. Ed. by Caprioli RM. Elsevier, Oxford, UK, pp 317-322, 2006
  6. Pajkoviċ N, van Breemen RB. Chapter 8: Analysis of carotenoids using atmospheric pressure chemical ionization mass spectrometry. In Modern Methods of Lipid Analysis. Ed. by Byrdwell WC. AOCS Press, Champaign, IL, pp 413-430, 2005
  7. Constantinou AI, van Breemen RB. Lycopene, a dietary cancer chemopreventive agent. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemoprevention Agents. Ed. by Kelloff GJ, Hawk ET, Sigman CC. Humana Press, Totowa, NJ, pp 525-535, 2004
  8. van Breemen RB. Mass spectrometry and drug discovery. In Burger’s Medicinal Chemistry and Drug Discovery. 6th Edition, Volume 1: Drug Discovery. Ed. By Abraham DJ. John Wiley & Sons, New York, 2003
  9. van Breemen RB. Introduction to mass spectrometry for food chemistry. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, Appendix 3A.1-3A.7, 2001
  10. van Breemen RB. Mass spectrometry of chlorophylls. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F4.5.1-F4.5.9, 2001
  11. van Breemen RB. Mass Spectrometry of carotenoids. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F2.4.1-F2.4.13, 2001.
  12. Barua AB, Olson JA, Furr HC, van Breemen RB. Vitamin A and carotenoids. In Modern Chromatographic Analysis of the Vitamins, 3rd ed. Ed. by De Leenheer A, Lambert WE, Van Bocxlaer JF. Marcel Dekker, Inc., New York, pp 1-74, 2000
  13. Fitzloff JF, Yat P, Lu LL, Awang, DVC, Arnason JT, van Breemen RB, Hall T, Blumenthal M, Fong HHS. Perspectives on the quality assurance of ginseng products in North America. In Advances in Ginseng Research – Proceedings of the 7th International Symposium on Ginseng. Ed. by Huh H, Choi KJ, Kim YC. The Korean Society of Ginseng, Seoul, Korea, September 22-25, 1998
  14. van Breemen RB, Woodbury CP, Venton DL. Screening molecular diversity using mass spectrometry. In Mass Spectrometry of Biological Molecules, 2nd ed. Ed. by Larsen BS, McEwen CN. Marcel Dekker, New York, pp 99-113, 1998
  15. van Breemen RB. Mass spectrometry of textile dyes. In Advances in Colour Chemistry Series, pp. 96-116, Ed. by Peters AT, Freeman HS. Blackie Academic & Professional, Chapman and Hall, Glasgow, 1995. Invited contribution.
  16. van Breemen RB. Structural analysis of phosphatidylinositol from carrot cell membranes by fast atom bombardment and tandem mass spectrometry. In Mass Spectrometry in the Molecular Sciences: A Tutorial, pp 443-451, ed. by Gross ML. Kluwer Academic Publishers, Dordrecht, 1992. Invited contribution.
  17. van Breemen RB, Fenselau CC, Dulik DM. Activated Phase II metabolites: Comparison of alkylation by 1-O-acyl glucuronides and acyl sulfates. in Biological Reactive Intermediates III. Ed. by Kocsis JJ, Jollow DJ, Whitmer CM, Nelson JO, Snyder R. pp. 423-429, Plenum Publishing, New York, 1986
Patents
  1. UNITED STATES PATENT No. 6,995,022 Screening of xenobiotics and endogenous compounds for metabolic transformation, formation of toxic metabolites, and bioavailability. 2006 February 7. Full Text
  2. UNITED STATES PATENT No. 5,872,015 Molecular diversity screening method. 1999 February 16. Full Text
  3. UNITED STATES PATENT No. 9,040,096 Jasmonic acid compounds in cocoa products. 2015 May 26. Full Text